Cellular uptake studies of antisense oligonucleotides using G-quadruplex-nanostructures. The effect of cationic residue on the biophysical and biological properties
نویسنده
چکیده
Institute of Advanced Chemistry of Cata E-08034 Barcelona, Spain. E-mail: recgma@ Networking Centre on Bioengineering, Biom Spain University of Barcelona, Department of Chemistry, Mart́ı i Franquès 1-11, E-08028 † Electronic supplementary information (E H-NMR and C-NMR spectra, HPLC pro thermal denaturation experiments, nati conjugates, MTT colorimetric assay, tr conditions, ow cytometry analyses. See D Cite this: RSC Adv., 2016, 6, 76099
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Biophysical and biological properties of quadruplex oligodeoxyribonucleotides.
Single-stranded guanosine-rich oligodeoxyribonucleotides (GROs) have a propensity to form quadruplex structures that are stabilized by G-quartets. In addition to intense speculation about the role of G-quartet formation in vivo, there is considerable interest in the therapeutic potential of quadruplex oligonucleotides as aptamers or non-antisense antiproliferative agents. We previously have des...
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